Muza suffered a 2-0 defeat to Diables Noirs in the second leg of the CAF Confederations Cup on Sunday in Congo.
Following the result in Brazaville, Muza how out of the competition via a 4-1 aggregate.
In East Africa, Zambian Champions Power Dynamos were also eliminated from the CAF Champions League on away goal rule.
Despite holding Simba to a 1-1 draw, the Kitwe giants have exited the competition via a 3-3 aggregate.
The two clubs will now turn their attention to the Zambian Super League.